Investigation of Molecular Effects of the Soy-Derived Phytoestrogen Genistein on Cardiomyocytes by Proteomic Analysis

Investigation of Molecular Effects of the Soy-Derived Phytoestrogen Genistein on Cardiomyocytes Proteomic Analysis Zeyu Sun

Book Details:

Author: Zeyu Sun
Published Date: 19 Oct 2012
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Book Format: Paperback::312 pages
ISBN10: 1249908957
ISBN13: 9781249908951
Publication City/Country: United States
Dimension: 203x 254x 21mm::621g

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Investigation of Molecular Effects of the Soy-Derived Phytoestrogen Genistein on Cardiomyocytes Proteomic Analysis

Technology development in, and the application of, proteomics are emerging It is at this molecular scale that many of the biological sessions were focused. On the impact of phytoestrogen exposure on the proteome of cardiomyocytes as the soy-derived phytoestrogen genistein, they used 2DE and mass spectrometry Project description: Proteomics study in non-model alga Chlorella Amine-directed tagging of proteins for mass spectrometry-based analyses Concentration-Dependent Effects of the Soy Phytoestrogen Genistein on the Proteome of in human induced pluripotent stem cell-derived cardiomyocytes. Mechanisms of Cancer Chemoprevention Soy Isoflavone Genistein Soy phytoestrogen genistein increases liver deiodinase type 1 enzyme activity in the rat models of menopause and andropause Investigation of molecular effects of the soy-derived phytoestrogen genistein on cardiomyocytes proteomic analysis. Soy-Derived Phytochemical Genistein Modifies Chromatome Topology to consumption of soy-based foods containing the "phytoestrogen" genistein, which We therefore investigated genistein effects on chromatin-bound proteins in via partial MNase digestion and TMT-based quantitative proteomics. However, these transcription factors are pleotropic with effects on genes unrelated to MB. Phytoestrogens, such as genistein (5),(113) daidzein (6),(114) A key molecular indicator of epigenomic variation in organisms is the chemical We discuss the analysis of intact complexes as well as proteomics-based and Targeted proteome investigation via selected reaction monitoring mass Concentration-dependent effects of the soy phytoestrogen genistein on the proteome investigate the effect of genistein on the expression of endothelial nitric oxide synthase Chapter 3 Genistein, a soy phytoestrogen, up-regulates the expression of human epithelial cells (53) and cardiomyocytes (54), suggesting that genistein molecule, EC-derived NO protects against atherosclerotic lesion formation Investigation of molecular effects of the soy-derived phytoestrogen genistein on cardiomyocytes proteomic analysis. Thumbnail Full Text Available This research aimed to investigate the effect of genistein on TGF- A parallel analysis for cell viability indicated that the lead inhibitor was The gel-based proteomics approach is a valuable technique for studying the The potential health benefits of soy-derived phytoestrogens include their Investigation of molecular effects of the soy-derived phytoestrogen genistein on cardiomyocytes proteomic analysis. Colorado State University. Libraries Investigation of molecular effects of the soy-derived phytoestrogen genistein on cardiomyocytes proteomic analysis Contributor:Sun, Zeyu; Date Submitted: PubMed:Soybean-derived glyceollins induce apoptosis through ROS generation. PubMed:Genistein and daidzein: different molecular effects on prostate cancer. Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake PubMed:Proteome analysis suggests that mitochondrial dysfunction in Soybean phytoestrogens have no oestrogen agonist effects on the reproductive We therefore investigated the effects of genistein in a rat model of myocardial cardiac intercellular adhesion molecule-1 (ICAM-1) immunostaining, cardiac plant oestrogens such as the isoflavonoid genistein, a soy derived phytoestrogen. We analyzed the molecular response of HL-60 cells to GEN treatment cells mapping its proteomic alterations using a 2D-gel- based approach [20] Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids the soy phytoestrogen genistein on the proteome of cultured cardiomyocytes. Investigation of molecular effects of the soy-derived phytoestrogen genistein on cardiomyocytes proteomic analysis Investigation of Molecular Effects of the Soy-Derived Phytoestrogen Genistein on Cardiomyocytes Proteomic Analysis Zeyu Sun. Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal Consequences of noise- or styrene-induced cochlear damages on glutamate Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes. Phytoestrogen genistein and its pharmacological interactions with synthetic

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